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So how does this DNA store
information?
DNA has long chemical
polymers or strands made up of chains of molecules. There are two
strands twisted into a double helix. The strands are linked by
four types of base molecules or bases.
These are four bases: guanine, cytosine, thymine and adenine. The
bases can only fit or link or pair together as follows guanine
with cytosine, and thymine with adenine.
The difference between one DNA molecule and another depend on the
pattern or sequence of these base pairings along the length
of the polymer double helix. This sequence of base pairs
represents the genetic code, which controls the development of the
organism.
A
single strand of DNA can be over 10,000 base units long. In a
typical mammalian cell, there are 2.5 billion base pairs. Genes
are units on the DNA molecule. Therefore, there are almost an
unlimited number of genes in plants and animals.
Genes with completely new
capabilities or characteristic can only be created only when
mistakes occur in the DNA replication or copying process.
A mistake in the DNA
replication is called a mutation. The
mutation is usually small a very small error in the genetic code
and the rate of mutation in normal organisms is extremely low.
The probability of any
particular base position in a DNA chain being miscopied on any one
copying occasion is approximately one in a 1,000,000,000 (1
billion), but they do happen but it takes a considerably length of
time for a mutation to occur.
The lifetime of DNA messages
of genetic code is therefore measured in millions of years.
This simple modular structure is partly the key
to how nature has created complex, powerful, elegant,
awe-inspiring, incredibly capable organisms and species have
evolved, thrived, and survived for millions of years
Astonishingly,
genes
with completely new capabilities or characteristics
can only be created only when mistakes occur
in the DNA replication or copying process.
Mutation occurs when a
piece of the DNA is faulty. Mutation is known as an insurance
policy to maintain diversity within the population. Typically,
mutation occurs with a small frequency of occurrence - often less
than one in a million. Mutations are mostly bad causing inherited
diseases, but some are good, and lead to new worthwhile traits or
features.
Mutations produce sudden and distinct
differences between individuals. The rate of mutation dictates the
speed of transition of the organisms. As new genes are introduced,
this increases the diversity of the population members, unlike the
process of recombination.
Slow, gradual,
cumulative, small steps of genetic change, involving mutations
over many generations, explains nature’s way of deriving complex
organisms that survive.
The cumulative
change over the generations is not random. Nature does not start
fresh again. The genes that go forward to the next generation are
selected, based on the traits that are derived from the genes.
This selection of these traits, is determined by the current
environment, not the future environment. The selection is made
through competition for food, mates, and shelter, as well as
disease, and predation.
Cumulative
selection can manufacture complexity and great designs, but it
cannot work unless there is some machinery of replication – a
replicator engine. The replicator is ultimate engine of life. It
is nature’s only strategy.
The
mutation rate dictates the transformation rate. It introduces new
genes.
The two simple
properties of self replication – the basic ingredient of
cumulative selection or life are
1)
the power over their
own future – to carry forward the traits from the genes passed on
– taking the best of today forward.
2)
mistakes are made,
although DNA copying incorporates proof reading drills or controls
Very
occasionally, a mutation or new gene will
give an organism a survival advantage over its relatives in the
environment. This is specially so when
the environment changes. It allows the organism to fit the
environment better.
This is the ‘survival of
the fittest’ or natural selection. This
mutation and selection process drives evolution. A good example is
a mutation in bacteria that makes it resistant to antibiotics, so
the mutant gene lives on, in the offspring, creating a resistant
or surviving strain of bacteria.
There are
two ways we can learn from nature here
Mistakes in business are 85%
down to the system or process and about 15% down the people.
There should be no stigma to finding a mistake. Correct the
system, don't blame the people. Learn and
move on.
Develop the tactic of asking ...What
went well? What went not so well?...of
everything, then eliminate the not so wells.
It is important to note, that
the mutation rate can be increased in human cells by the exposure
to radiation and certain chemicals...mutation
pressure.
In business
we have the possibility of creating a "mutation pressure" in a
nice and controlled way. Create risk free experiments, build
prototypes, try new ways of work, stimulate ideas and suggestions.
Note, many
new inventions have come from applying existing knowledge to
different areas.
Create
a way of randomly generating small, harmless accidents or ideas
that sometimes produce breakthroughs in business or give you the
mutant gene that will make you immune to a disease or competition.
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